Oligonucleotide Analogues as Potential Chemotherapeutic Agents
Identifieur interne : 004C60 ( Main/Exploration ); précédent : 004C59; suivant : 004C61Oligonucleotide Analogues as Potential Chemotherapeutic Agents
Auteurs : Gerald Zon [États-Unis]Source :
- Pharmaceutical Research [ 0724-8741 ] ; 1988-09-01.
English descriptors
Abstract
Abstract: Oligonucleotides specifically bind to complementary sequences of either genomic DNA or genomic RNA through hydrogen bonding of base pairs. In principle, relatively short oligomers (<20 bases) can specifically hybridize with DNA or RNA and thus be used for novel drug design strategies involving targeted interference of genetic expression at the level of transcription or translation. Conceivable chemotherapeutic applications predicated on sequence-specific hybridization (“antisense” inhibition) require oligonucleotide analogues that are resistant to in vivo degradation by enzymes such as nucleases. Nuclease-resistant analogues having modified internucleoside linkages (e.g., methylphosphonates or phosphorothioates) or modified nucleosides (e.g., 2′-0-methylribose or α-anomers) are now readily available by means of automated synthesis, and there are various classes of pendant groups (e.g., alkylating or intercalating agents) that can be attached to increase the efficacy of these analogues. The present account reviews this area of research by classifying structures and mechanisms of action, with comments on stereochemistry. Biological studies are briefly summarized, and pharmaceutically related topics of interest are noted.
Url:
DOI: 10.1023/A:1015985728434
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000504
- to stream Istex, to step Curation: 000504
- to stream Istex, to step Checkpoint: 002147
- to stream Main, to step Merge: 004D40
- to stream Main, to step Curation: 004C60
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oligonucleotide Analogues as Potential Chemotherapeutic Agents</title><author><name sortKey="Zon, Gerald" sort="Zon, Gerald" uniqKey="Zon G" first="Gerald" last="Zon">Gerald Zon</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:EFD257C8958AFA7B5406C5BA01F2BD30E514B3C2</idno><date when="1988" year="1988">1988</date><idno type="doi">10.1023/A:1015985728434</idno><idno type="url">https://api.istex.fr/ark:/67375/1BB-WK1486Q0-X/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000504</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000504</idno><idno type="wicri:Area/Istex/Curation">000504</idno><idno type="wicri:Area/Istex/Checkpoint">002147</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002147</idno><idno type="wicri:doubleKey">0724-8741:1988:Zon G:oligonucleotide:analogues:as</idno><idno type="wicri:Area/Main/Merge">004D40</idno><idno type="wicri:Area/Main/Curation">004C60</idno><idno type="wicri:Area/Main/Exploration">004C60</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Oligonucleotide Analogues as Potential Chemotherapeutic Agents</title><author><name sortKey="Zon, Gerald" sort="Zon, Gerald" uniqKey="Zon G" first="Gerald" last="Zon">Gerald Zon</name><affiliation wicri:level="2"><country>États-Unis</country><placeName><region type="state">Californie</region></placeName><wicri:cityArea>Applied Biosystems, 777 Lincoln Centre Drive, 94404, Foster City</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Pharmaceutical Research</title><title level="j" type="sub">An Official Journal of the American Association of Pharmaceutical Scientists</title><title level="j" type="abbrev">Pharm Res</title><idno type="ISSN">0724-8741</idno><idno type="eISSN">1573-904X</idno><imprint><publisher>Kluwer Academic Publishers-Plenum Publishers</publisher><pubPlace>New York</pubPlace><date type="published" when="1988-09-01">1988-09-01</date><biblScope unit="volume">5</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="539">539</biblScope><biblScope unit="page" to="549">549</biblScope></imprint><idno type="ISSN">0724-8741</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0724-8741</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>antisense oligonucleotides</term><term>targeted drugs</term><term>translation arrest</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Oligonucleotides specifically bind to complementary sequences of either genomic DNA or genomic RNA through hydrogen bonding of base pairs. In principle, relatively short oligomers (<20 bases) can specifically hybridize with DNA or RNA and thus be used for novel drug design strategies involving targeted interference of genetic expression at the level of transcription or translation. Conceivable chemotherapeutic applications predicated on sequence-specific hybridization (“antisense” inhibition) require oligonucleotide analogues that are resistant to in vivo degradation by enzymes such as nucleases. Nuclease-resistant analogues having modified internucleoside linkages (e.g., methylphosphonates or phosphorothioates) or modified nucleosides (e.g., 2′-0-methylribose or α-anomers) are now readily available by means of automated synthesis, and there are various classes of pendant groups (e.g., alkylating or intercalating agents) that can be attached to increase the efficacy of these analogues. The present account reviews this area of research by classifying structures and mechanisms of action, with comments on stereochemistry. Biological studies are briefly summarized, and pharmaceutically related topics of interest are noted.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Zon, Gerald" sort="Zon, Gerald" uniqKey="Zon G" first="Gerald" last="Zon">Gerald Zon</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004C60 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004C60 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:EFD257C8958AFA7B5406C5BA01F2BD30E514B3C2
|texte= Oligonucleotide Analogues as Potential Chemotherapeutic Agents
}}
| This area was generated with Dilib version V0.6.33. |  |